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pentobarbital will minimize the extent or influence of pitolisant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Closely. Pitolisant publicity is decreased by fifty% if coadministered with solid CYP3A4 inducers.pentobarbital will increase toxicity of ifosfamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism